Most Recent Articles: Acta Neuropathologica Communicationshttps://actaneurocomms.biomedcentral.comMost Recent Articles: Acta Neuropathologica CommunicationsNeuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseaseshttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01758-3Recent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rather than the tau pathology. However, confirmation using gold standard neuropathological...ResearchWed, 27 Mar 2024 00:00:00 GMThttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01758-3Masanori Kurihara, Tomoyasu Matsubara, Satoru Morimoto, Akira Arakawa, Kensuke Ohse, Kazutomi Kanemaru, Atsushi Iwata, Shigeo Murayama and Yuko Saito2024-03-27T00:00:00ZMRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndromehttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01757-4Sturge-Weber syndrome (SWS), a neurocutaneous disorder, is characterized by capillary malformations (CM) in the skin, brain, and eyes. Patients may suffer from seizures, strokes, and glaucoma, and only symptom...ResearchTue, 26 Mar 2024 00:00:00 GMThttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01757-4Sana Nasim, Colette Bichsel, Stephen Dayneka, Robert Mannix, Annegret Holm, Mathew Vivero, Sanda Alexandrescu, Anna Pinto, Arin K. Greene, Donald E. Ingber and Joyce Bischoff2024-03-26T00:00:00ZChronic hypoxia remodels the tumor microenvironment to support glioma stem cell growthhttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01755-6Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research tool useful for investigating the role of the human brain tumor microenvironment in gliob...ResearchMon, 25 Mar 2024 00:00:00 GMThttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01755-6J. G. Nicholson, S. Cirigliano, R. Singhania, C. Haywood, M. Shahidi Dadras, M. Yoshimura, D. Vanderbilt, B. Liechty and H. A. Fine2024-03-25T00:00:00Zβ1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matterhttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01749-4Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular integrity in the brain, particularly under vascular remodeling conditions. As blood vessels...ResearchWed, 20 Mar 2024 00:00:00 GMThttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01749-4Sebok K. Halder, Arjun Sapkota and Richard Milner2024-03-20T00:00:00ZHuman adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signalinghttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01753-8Microglia-mediated neuroinflammatory responses are recognized as a predominant factor during high intraocular pressure (IOP)-induced retinal and optic nerve injury along with potential therapeutic targets for ...ResearchTue, 19 Mar 2024 00:00:00 GMThttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01753-8Shangli Ji, Yanfang Peng, Jian Liu, Pang Xu and Shibo Tang2024-03-19T00:00:00Z